"According to GW Pharmaceuticals, the prospectively defined primary efficacy endpoint of the study - the difference between the mean change in spasticity severity of Sativex vs Placebo in Phase B - was highly statistically significantly in favour of Sativex (p=0.0002). The numeric difference between the two groups as measured on a numeric rating scale was 0.84 units from a baseline of 3.89, greater than that achieved in previous studies.
The difference between Sativex and placebo was also significant for a number of secondary endpoints. Approximately 74% of Sativex patients achieved an improvement of greater than 30% in their spasticity score over the entire study versus 51% on placebo (p=0.0003), the company said. "