caution larry

Hi, I’m Kim! This site provides a little insight to my journey of being diagnosised with Remitting Relapsing Multiple Sclerosis on October 26th 2004. I review books and documentaries, post MS-related news, and share my photos.

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Tuesday, February 10, 2009
Vitamin D Deficiency May Increase MS Risk
Well, well, well... finally! A link to MS with the infamous Vitamin D we've all been hearing about for many years. And I find it quite cool to also see an environmental trigger identified to tell me why I have MS! Go research go!

"The findings could explain why MS, an autoimmune condition in which the body mistakenly attacks brain tissue and nerves, is relatively rare in countries near the sunny equator. MS is much more common in the darker and gloomier northern latitudes (and far southern latitudes).

Other studies have suggested that people with MS were more likely to have been born in the spring (with the bulk of pregnancy during the dark winter months) than in the fall. Sunlight is the main source of vitamin D, although it’s also found in salmon, mackerel, tuna fish, and as an additive to milk and other products.

“It’s a phenomena found over and over again, says Moses Rodriguez, MD, a professor of neurology at the Mayo Clinic in Minnesota, who was not involved in the new research. “This study provides some link that vitamin D may be one of the environmental factors that predisposes people to MS.

No one really knows the exact cause of MS, but researchers suspect it’s a combination of genes and environmental factors. About 2.5 million people worldwide have MS.

In the study, researchers from the University of Oxford and the University of British Columbia looked at a gene variant known as DRB1*1501, which is associated with MS. About 1 in 100 people who inherit two copies of the gene (one from each parent) develop MS, compared to 1 in 300 who have only one copy and 1 in 1,000 of those in the general population.

The researchers found that proteins activated by vitamin D bind to a DNA sequence next to the DRB1*1501 variant, which switches the gene on. If too little vitamin D is present, the gene may not function properly, which may cause a susceptibility to MS.

"We were surprised to find the [vitamin] D connection," says study coauthor George Ebers, action research professor of clinical neurology at the University of Oxford. “We suspect women who are planning to have children may benefit from taking D in regions where they are likely to be deficient.

There is no proof that vitamin D will prevent, treat, or cure the disease. However, the researchers suspect that a lack of vitamin D during early life may prevent the thymus, an immune system gland that sits on the top of the heart, from deleting harmful white blood cells.

These cells, known as T cells, may go on to attack the central nervous system and damage myelin, the insulation that protects nerves. In MS, this abnormal immune response affects nerve impulses to and from the brain. Symptoms of MS include numbness in the limbs, pain, coordination problems, vertigo, and vision impairment, depending on the nerves that are affected.