Mandatory Rest Period

For those that are interested in new results that have come in on childhood MS, I have pdf copies of this full report. Send me a quick email and I'll send you a copy. Most interesting to me is the exposure to Epstein Barr Virus (EBV or aka Mononeucleosis). I've had it and within a year had my first symptoms of MS although I was already 23 at that time. Who else with MS has had Mono?

"Over 80% of the children with MS, irrespective of
geographical residence, were seropositive for remote EBV
infection. Seropositivity for EBV was associated with an
almost three times increased likelihood of MS compared
with age-matched and region-matched controls. Children
with MS also had signifi cantly higher EBV-EBNA1 titres,
and were more likely to have EBV titres in the highest
tertile, than controls. The higher EBV titres could represent
heightened immunological responses to EBV, as has been
suggested in a similar analysis comparing EBNA1 titres in
EBV-positive adult MS patients and controls.35 Studies of
T-cell proliferation to HLA-restricted EBV antigens in EBVpositive
children with MS compared with EBV-positive
healthy children are now underway. Increased EBV titres
might be due to episodic viral reactivation, a process that
has been postulated to occur with greater frequency in MS
patients than in individuals without MS, especially in
association with MS relapses.51 PCR analysis of EBV DNA
in saliva or plasma is required to ascertain lytic cycle
occurrence, and to correlate this with clinical disease
activity. Of note, to minimise potential cross-reactivity with
self-antigens, we specifi cally selected an EBNA-1 EIA assay
that relies on synthetic peptides, and excluded the Gly-Ala
repetitive sequence known to cross-react with self epitopes
from collagen, keratin, and actin.

- posted by Anonymous @ 12:55 PM - Link @ 12:55 PM - Link to this post - Comments (0)

			Hi, I’m Kim! This site provides a little insight to my journey of being diagnosised with Remitting Relapsing Multiple Sclerosis on October 26th 2004. I review books and documentaries, post MS-related news, and share my photos. Subscribe (RSS) My bloglines Archives Current November 2004 December 2004 January 2005 February 2005 March 2005 April 2005 May 2005 June 2005 July 2005 August 2005 September 2005 October 2005 November 2005 December 2005 January 2006 February 2006 March 2006 April 2006 May 2006 June 2006 July 2006 August 2006 September 2006 October 2006 November 2006 December 2006 January 2007 February 2007 March 2007 April 2007 May 2007 June 2007 July 2007 August 2007 September 2007 October 2007 November 2007 December 2007 January 2008 February 2008 March 2008 April 2008 May 2008 June 2008 July 2008 August 2008 September 2008 October 2008 November 2008 December 2008 January 2009 February 2009 March 2009 April 2009 May 2009 June 2009 July 2009 August 2009 September 2009 October 2009 November 2009 December 2009 January 2010 February 2010 March 2010 May 2010 June 2010 July 2010 September 2010 November 2011

	Tuesday, November 13, 2007 *Multinational Childhood Study* For those that are interested in new results that have come in on childhood MS, I have pdf copies of this full report. Send me a quick email and I'll send you a copy. Most interesting to me is the exposure to Epstein Barr Virus (EBV or aka Mononeucleosis). I've had it and within a year had my first symptoms of MS although I was already 23 at that time. Who else with MS has had Mono? "Over 80% of the children with MS, irrespective of geographical residence, were seropositive for remote EBV infection. Seropositivity for EBV was associated with an almost three times increased likelihood of MS compared with age-matched and region-matched controls. Children with MS also had signifi cantly higher EBV-EBNA1 titres, and were more likely to have EBV titres in the highest tertile, than controls. The higher EBV titres could represent heightened immunological responses to EBV, as has been suggested in a similar analysis comparing EBNA1 titres in EBV-positive adult MS patients and controls.35 Studies of T-cell proliferation to HLA-restricted EBV antigens in EBVpositive children with MS compared with EBV-positive healthy children are now underway. Increased EBV titres might be due to episodic viral reactivation, a process that has been postulated to occur with greater frequency in MS patients than in individuals without MS, especially in association with MS relapses.51 PCR analysis of EBV DNA in saliva or plasma is required to ascertain lytic cycle occurrence, and to correlate this with clinical disease activity. Of note, to minimise potential cross-reactivity with self-antigens, we specifi cally selected an EBNA-1 EIA assay that relies on synthetic peptides, and excluded the Gly-Ala repetitive sequence known to cross-react with self epitopes from collagen, keratin, and actin. - posted by Anonymous @ 12:55 PM - Link @ 12:55 PM - Link to this post - Comments (0)