caution larry

Hi, I’m Kim! This site provides a little insight to my journey of being diagnosised with Remitting Relapsing Multiple Sclerosis on October 26th 2004. I review books and documentaries, post MS-related news, and share my photos.

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Wednesday, February 28, 2007
 
MBP8298 moving along for those that are SPMS

2007-02-28 15:10:36


The first phase of testing
is done
and now those patients on placebo can carry on with the actual drug.
I wonder what that feels like when you find out you were on the placebo? Anyone
have that experience? Were you convinced you were actually on the drug? "Eligible
patients who have successfully completed the blinded, placebo controlled MAESTRO-01
trial may choose to receive MBP8298 on an un-blinded basis in MAESTRO-02 regardless
of whether they were previously on placebo or drug. The trial will primarily
evaluate the long-term safety of MBP8298. "Now that the first patients
who participated in our MAESTRO-01 pivotal trial have completed the study, we
are pleased to offer MBP8298 on an open-label basis," said Kevin Giese, President
and CEO of BioMS Medical. "We believe MBP8298 has the potential to become the
only safe and effective first line therapy for the treatment of secondary progressive
MS. While MAESTRO-01 was designed to evaluate the safety and efficacy of MBP8298,
MAESTRO-02 will provide additional important long-term safety and efficacy data
to support regulatory submissions."



Wednesday, February 21, 2007
 
The Pregnancy Connection - Prolactin?

2007-02-21 08:43:23

So, I've always wondered why they say that women are less likely to feel MS symptoms while pregnant. One, I guess, can assume that with the harmonal and immune system changes to allow the baby to grow must be the ticket right? So why hasen't anyone bottled that up and given it to us MS'ers?! Seems like it's on its way to happening perhaps? Okay, at least in mice they are finding out it's all about Prolactin. And I'm also very happy to see that Dr. Jock Murray is commenting on this research! Good to see that name again! "Prolactin stimulates breast development and milk production and has been tested in humans for other reasons. "It's early to be confident that prolactin will definitely work with people," said Weiss. "But prolactin represents the first example of any molecule, in this case a naturally occurring molecule, that can actually boost the repair of myelin." The Calgary team compared pregnant and virgin female mice of the same age to count the number of myelin-producing cells. They found pregnant mice had:

  • Twice as many of the cells.
  • 50 per cent more myelin coating their nerve cells after giving birth.
  • Twice as much new myelin after it was chemically destroyed.


Tuesday, February 20, 2007
 
Newer MRI machines are great
2007-02-20 14:13:12

Just had my MRI and it was GREAT! I talked to the nice nurse ahead of time
to ask if he would let me know the half way point and not leave me guessing
in the tube. That happened last time and it really unnerved me. I'm not clausterphobic,
but lying in that tube without knowing how much time has passed or how much
more time needs to pass is just not fun. And this new machine (he said only
about a year old) has a music system! I ended up listening to the musical Rent
:) This machine also had different noises. Not much of the knocking sound I
remember from 2 years ago. Cuter noises if thats possible. Not so grating :)
So, one week for the results to be sent to my doc. Glad its done.



Monday, February 19, 2007
 
Caregiver burden in multiple sclerosis
2007-02-19 10:32:20

Oh no, look what we do! ;) Kidding, kidding. Interesting study. There's no doubt MS is a family disease and the impact is not just on the MS patient. Good thing to know and remember. "CONCLUSION: Caregivers of patients with MS experience high levels of distress and reduced quality of life. Psychiatric symptoms and cognitive impairment contributed significantly to caregiver distress, over and above the effect of disability due to neurological symptoms."
An accomplishment
2007-02-19 11:56:06

I'm not sure I've ever knitted something for me... but here it is! A finished sweater finally! I only started it last October so it feels pretty darn good to be able to put it on while the weather remains cool enough! Okay, now back to hiding out from the rain... it's coming down in buckets today so I'm making soup. Miso Barley Tofu soup. Might be good, might be bad. We'll see ;)
Okay, I'll admit it
2007-02-19 11:57:13

I heart Dog the Bounty Hunter. So I looked him up while I was killing time in Honolulu. :) No, I didn't phone him and waste his time. But it would have been cool to see him out and about!
2 1/2 months instead of 7!
2007-02-19 18:01:34

I just got called in for my MRI tomorrow morning! Cancellation lists ROCK. This machine will let me listen to music! Yay! I keep hearing about everyone else scattered across this earth who get that as an option. Now... what to bring... Tod thinks I should burn 45 minutes of podcasts. Hmmm...



Wednesday, February 14, 2007
 
Kauai!
2007-02-14 14:25:57

Okay, so it was Kauai that I was vacationing in :) It was lovely, relaxing, and so nice and slow paced. Loved bobbing around in the ocean and really not doing much of anything. I even have a bit of a tan! I guess I got my dose of Vitamin D. I overheated once while hiking up from a beach. It made my legs so numb and my eye sight so wonky I had to just sit in the car and let the AC cool me down. Blech. Other than that, I didn't really feel too many MS symptoms although my legs seems to be pretty fuzzy these last couple of days being home. I wonder now if I was feeling that sensation less in the heat and now coming home to the cold I'm feeling it again? Who knows! My back didn't fair that great on the poor quality bed or the long, long plane ride home. I can't wait to see my massage therapist. A new love I discovered while there is a Tangelo. YUM. I have never sat on a beach and enjoyed a piece of fruit more than that juicy, delicious tangelo! I wish i could buy them here locally. The other new love is Kona coffee, chocolate macadamia nut flavour. Mmmm.

MRI May Predict Multiple Sclerosis' Effect on Brain
2007-02-14 15:09:14

I guess this news shouldn't be all that surprising, but MRI changes can predict future course of disabilty in early years of diagnosis. "Changes in brain volume over the two years were calculated, and the study volunteers also underwent assessment for changes in neurologic disability. "The mean (average) annualized rate of cerebral atrophy was - 0.9 percentage of brain volume changed per year," the researchers wrote. Two factors -- brain volume at baseline and the brain's "T2 lesion load" -- explained 31.2 percent of the variance in percentage of brain volume change per year, the researchers concluded. This means that "patients who have acquired more brain tissue loss and more T2 lesions are prone to have a higher rate of subsequent brain atrophy," the study authors concluded. "In this relationship, the extent of brain tissue loss seemed more important than lesional activity. Because a higher rate of cerebral atrophy is predictive of worse clinical functioning at a later stage in the MS disease course, our findings suggest that these two baseline variables could have prognostic value for clinical functioning in early MS," the team said."

Benign MS often not so benign
2007-02-14 15:28:07

Well, well, well... so the disease can be "MS lite" in the first few years but ends up just the same as any other RRMS'er. Good to know. And look! Thats my Neurolgist who co-author'ed this report! I'll have to ask her about it when i see her next year. "Patients who are told they have benign MS should be regularly assessed to see whether subtle neurological changes that might herald later progression of the disease could be picked up early, the researchers with the University of British Columbia Hospital MS Clinic recommend. Those who experience few symptoms for the first 10 years are often told they have a mild form of the illness and will never suffer severe problems. But the researchers found that after 20 years the disease had progressed in nearly half of those diagnosed with benign MS, including 20 per cent who needed a cane to walk. "We hoped to identify risk factors that make people more likely to progress in the disease after 10 years of a benign course, but we did not find that gender, the symptoms when the disease began or age when the disease began were associated with either disease progression or remaining benign," said study co-author Dr. Virginia Devonshire. "More research needs to be done to identify criteria to determine which people will remain with mild disability over the long term."



 
Kauai!
2007-02-14 14:25:57

Okay, so it was Kauai that I was vacationing in :) It was lovely, relaxing, and so nice and slow paced. Loved bobbing around in the ocean and really not doing much of anything. I even have a bit of a tan! I guess I got my dose of Vitamin D. I overheated once while hiking up from a beach. It made my legs so numb and my eye sight so wonky I had to just sit in the car and let the AC cool me down. Blech. Other than that, I didn't really feel too many MS symptoms although my legs seems to be pretty fuzzy these last couple of days being home. I wonder now if I was feeling that sensation less in the heat and now coming home to the cold I'm feeling it again? Who knows! My back didn't fair that great on the poor quality bed or the long, long plane ride home. I can't wait to see my massage therapist. A new love I discovered while there is a Tangelo. YUM. I have never sat on a beach and enjoyed a piece of fruit more than that juicy, delicious tangelo! I wish i could buy them here locally. The other new love is Kona coffee, chocolate macadamia nut flavour. Mmmm.
MRI May Predict Multiple Sclerosis' Effect on Brain
2007-02-14 15:09:14

I guess this news shouldn't be all that surprising, but MRI changes can predict future course of disabilty in early years of diagnosis. "Changes in brain volume over the two years were calculated, and the study volunteers also underwent assessment for changes in neurologic disability. "The mean (average) annualized rate of cerebral atrophy was - 0.9 percentage of brain volume changed per year," the researchers wrote. Two factors -- brain volume at baseline and the brain's "T2 lesion load" -- explained 31.2 percent of the variance in percentage of brain volume change per year, the researchers concluded. This means that "patients who have acquired more brain tissue loss and more T2 lesions are prone to have a higher rate of subsequent brain atrophy," the study authors concluded. "In this relationship, the extent of brain tissue loss seemed more important than lesional activity. Because a higher rate of cerebral atrophy is predictive of worse clinical functioning at a later stage in the MS disease course, our findings suggest that these two baseline variables could have prognostic value for clinical functioning in early MS," the team said."
Benign MS often not so benign
2007-02-14 15:28:07

Well, well, well... so the disease can be "MS lite" in the first few years but ends up just the same as any other RRMS'er. Good to know. And look! Thats my Neurolgist who co-author'ed this report! I'll have to ask her about it when i see her next year. "Patients who are told they have benign MS should be regularly assessed to see whether subtle neurological changes that might herald later progression of the disease could be picked up early, the researchers with the University of British Columbia Hospital MS Clinic recommend. Those who experience few symptoms for the first 10 years are often told they have a mild form of the illness and will never suffer severe problems. But the researchers found that after 20 years the disease had progressed in nearly half of those diagnosed with benign MS, including 20 per cent who needed a cane to walk. "We hoped to identify risk factors that make people more likely to progress in the disease after 10 years of a benign course, but we did not find that gender, the symptoms when the disease began or age when the disease began were associated with either disease progression or remaining benign," said study co-author Dr. Virginia Devonshire. "More research needs to be done to identify criteria to determine which people will remain with mild disability over the long term."



Monday, February 12, 2007
 
I'll give you a hint...
2007-02-12 11:44:24











This is where I've been for the last 10 days! Any guesses?